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- SPECIFICATION
- BACKGROUND
- DOCUMENTS
- REVIEW
ADDITIONAL INFORMATION
SYNONYMS
HD2; RPD3; YAF1; KDAC2; HDAC2
REACTIVITY
Human,Mouse,Rat
TESTED APPLICATIONS
ELISA,WB,IP
RECOMMENDED DILUTION
WB,1:500 - 1:1000|IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
CALCULATED MW
55kDa
OBSERVED MW
60kDa
IMMUNOGEN
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HDAC2 (NP_001518.3).
POSITIVE SAMPLES
HeLa,293T,NIH/3T3,C6,Mouse liver
CELLULAR LOCALIZATION
Cytoplasm,Nucleus,
STORAGE BUFFER
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
BACKGROUND
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
REVIEW
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