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Reactivity | Human Rat |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
Calculated MW | 187kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human EIF2AK4 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | GCN2; PVOD2; |
Western blot analysis of extracts of various cell lines, using EIF2AK4 antibody.
Immunohistochemistry of paraffin-embedded rat brain using EIF2AK4 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human esophageal cancer using EIF2AK4 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of A549 cell using EIF2AK4 antibody. Blue: DAPI for nuclear staining.
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
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